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What is the EsoGuard test?
The EsoGuard DNA test detects abnormal esophageal cells to identify disease before it progresses. With ~90% sensitivity and ~99% negative predictive value at detecting Barrett's esophagus1,2,3 as well as esophageal adenocarcinoma,1,2 the EsoGuard test allows for detection of these conditions so they can be effectively managed or treated.
Learn MoreClinical need
In the United States, esophageal cancer claims more lives than melanoma skin cancer and cervical cancer combined.
Only about 20% of patients diagnosed with esophageal cancer survive five years after diagnosis. Even early-stage cancer has a 5-year survival of only ~50%.4,5 This makes early detection of the easily treatable precancerous conditional critical for this highly lethal disease.
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The science
The EsoGuard assay uses targeted next generation sequencing (NGS) to examine individual DNA molecules for the presence or absence of cytosine methylation at 31 different genomic locations. EsoGuard assesses the presence of methylation in targeted regions of the Vimentin and CCNA1 genes after the samples have undergone bisulfite conversion—a chemical step which allows characterization of DNA methylation at CpG sites.
See the DataNon-Invasive Targeted Cell Collection
EsoCheck with Collect+Protect™ Technology is a quick, non-invasive way for clinicians to collect surface esophageal cells for analysis, without endoscopy. The small EsoCheck capsule, similar in size to a daily vitamin or gel cap, is easy for patients to swallow.
Learn About EsocheckWho is at risk?
The risk of esophageal precancer is highest in patients with gastroesophageal reflux disease (GERD), age over 50, male, white race, obesity, smoking, and a family history of esophageal precancer (Barrett's esophagus) or cancer (esophageal adenocarcinoma).6,7
At least thirty million at-risk individuals with gastroesophageal disease (GERD), also known as chronic heartburn, are recommended for esophageal precancer testing by professional society clinical practice guidelines to prevent highly lethal esophageal cancer. Precancer detection is essential because esophageal cancer survival rates are poor, even when detected at Stage I.
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Firefighters have a 62% increased risk of developing esophageal cancer and 39% increased risk of dying of the disease.8 The EsoGuard DNA test offers early detection for those at increased risk, which is why we partner with fire departments across the country to host convenient group screening events.
Host an EventInsurance + Billing
Lucid Diagnostics accepts all insurance plans and directly bills medical insurance carriers for the EsoGuard test.
Customer Service
Email: billing@luciddx.com
Phone: 1-888-582-4339
Monday-Friday 7:00am to 5:00pm PST